review for " Regions of very low H 3 K 27 me 3 partition the Drosophila genome into topological domains

, © Li et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and redistribution in any medium, provided that the original author and source are credited. The manuscript “Regions of very low H3K27me3 partition the Drosophila genome into topological domains” aims to investigate the mechanisms that partition the genome into TADs and the nature of domain boundaries. The authors investigated the Drosophila genome and identified two distinct domains: D domains which have very low H3K27me3 and E domains containing mid-to-high levels of H3K27me3. The D domains correlate with the boundaries of TADs, while the E domains generally correlate with TADs.